The amplitude of quantal currents is reduced during short-term depression at neuromuscular synapses in Drosophila

被引:9
作者
Adelsberger, H
Heckmann, M
Dudel, J
机构
[1] Physiologisches Institut, Tech. Universität München, D-80802 München
关键词
excitatory postsynaptic currents; desensitization; non-N-methyl-D-aspartate-receptor; synaptic plasticity;
D O I
10.1016/S0304-3940(97)00167-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Focal extracellular excitatory postsynaptic currents were recorded to investigate short-term depression at glutamatergic Drosophila neuromuscular synapses. The amplitudes of quantal excitatory postsynaptic currents (qEPSCs) elicited before and after depolarizations eliciting large release were compared. Depression reduced the amplitude of the qEPSCs to 0.65 +/- 0.14 of control. Recovery from depression and of the receptor channels from desensitization follow a similar time course. Thus receptor desensitization seems to be involved in short-term depression at Drosophila neuromuscular junctions. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:5 / 8
页数:4
相关论文
共 17 条
[1]   DEPRESSION OF TRANSMITTER RELEASE AT NEUROMUSCULAR JUNCTION OF FROG [J].
BETZ, WJ .
JOURNAL OF PHYSIOLOGY-LONDON, 1970, 206 (03) :629-&
[2]   STATISTICAL FACTORS INVOLVED IN NEUROMUSCULAR FACILITATION AND DEPRESSION [J].
DELCASTILLO, J ;
KATZ, B .
JOURNAL OF PHYSIOLOGY-LONDON, 1954, 124 (03) :574-585
[3]   CHANGES IN MINIATURE ENDPLATE POTENTIALS AFTER BRIEF NERVOUS STIMULATION AT THE FROG NEUROMUSCULAR-JUNCTION [J].
DOHERTY, P ;
HAWGOOD, BJ ;
SMITH, ICH .
JOURNAL OF PHYSIOLOGY-LONDON, 1984, 356 (NOV) :349-358
[4]  
DUDEL J, 1988, INT CONGR SER, V832, P405
[5]   DEPENDENCE OF DOUBLE-PULSE FACILITATION ON AMPLITUDE AND DURATION OF THE DEPOLARIZATION PULSES AT FROGS MOTOR-NERVE TERMINALS [J].
DUDEL, J .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1986, 406 (05) :449-457
[6]   CALCIUM DEPENDENCE OF QUANTAL RELEASE TRIGGERED BY GRADED DEPOLARIZATION PULSES TO NERVE-TERMINALS ON CRAYFISH AND FROG-MUSCLE [J].
DUDEL, J .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1989, 415 (03) :289-298
[7]   MECHANISM OF FACILITATION AT CRAYFISH NEUROMUSCULAR JUNCTION [J].
DUDEL, J ;
KUFFLER, SW .
JOURNAL OF PHYSIOLOGY-LONDON, 1961, 155 (03) :530-&
[8]  
EDMONDS B, 1995, ANNU REV PHYSIOL, V57, P495
[9]   RECORDINGS OF GLUTAMATE-GATED ION CHANNELS IN OUTSIDE-OUT PATCHES FROM DROSOPHILA LARVAL MUSCLE [J].
HECKMANN, M ;
DUDEL, J .
NEUROSCIENCE LETTERS, 1995, 196 (1-2) :53-56
[10]  
HECKMANN M, 1997, IN PRESS BIOPHYS J