Cord blood adiponectin and infant growth at one year

被引：18

作者：

Mazaki-Tovi, Shali ^{[1
]}

Kanety, Hannah ^{[2
,3
]}

Pariente, Clara ^{[3
]}

Hemi, Rina ^{[3
]}

Kuint, Jacob ^{[2
,4
]}

Yinon, Yoav ^{[1
]}

Schiff, Eyal ^{[1
,2
]}

Sivan, Eyal ^{[1
,2
]}

机构：

[1] Edmond & Lily Safra Children s Hosp, Sheba Med Ctr, Dept Obstet & Gynecol, Tel Hashomer, Israel

[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[3] Edmond & Lily Safra Children s Hosp, Inst Endocrinol, Sheba Med Ctr, Tel Hashomer, Israel

[4] Edmond & Lily Safra Children s Hosp, Dept Neonatol, Sheba Med Ctr, Tel Hashomer, Israel

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2011年 / 24卷 / 7-8期

关键词：

adipokines; appropriate for gestational age (AGA); fetus; neonatal growth; pregnancy; small for gestational age (SGA); FOR-GESTATIONAL-AGE; MATERNAL SERUM ADIPONECTIN; POLYCYSTIC-OVARY-SYNDROME; CATCH-UP GROWTH; BIRTH-WEIGHT; INSULIN SENSITIVITY; LEPTIN CONCENTRATIONS; PLASMA ADIPONECTIN; BODY-COMPOSITION; HUMAN-PREGNANCY;

D O I：

10.1515/JPEM.2011.181

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective : The aim of this study was to determine the association between cord blood adiponectin and leptin and early infant growth at one year in small for gestational age (SGA) and appropriate for gestational age (AGA) infants. Study design: In this prospective study adiponectin and leptin concentrations were determined in cord blood of (i) AGA newborns (n=44) and (ii) SGA newborns (n=24). At one year of age, height and weight were measured. Linear regression analysis was used to determine which factors were associated with anthropometric measurements at the age of one year. Results: (i) SGA neonates had a significantly lower median cord blood adiponectin and leptin than AGA neonates; (ii) among SGA neonates, cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year; and (iii) among AGA neonates cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year. Conclusion: The disparity in cord blood adiponectin and leptin concentrations between SGA and AGA neonates suggests a role for adipokines in fetal growth.

引用

页码：411 / 418

页数：8

共 79 条

[1]

Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age [J].

Bueno, Ana Carolina ;

Espineira, Aniette R. ;

Fernandes-Rosa, Fabio L. ;

de Souza, Roberto Molina ;

de Castro, Margaret ;

Moreira, Ayrton Custodio ;

Bettiol, Heloisa ;

Barbieri, Marco Antonio ;

Antonini, Sonir R. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2010, 162 (01) :53-60

[2]

Carrel AL, 2009, J PEDIATR ENDOCR MET, V22, P409

[3]

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism [J].

Catalano, P. M. ;

Hoegh, M. ;

Minium, J. ;

Huston-Presley, L. ;

Bernard, S. ;

Kalhan, S. ;

Mouzon, S. Hauguel-De .

DIABETOLOGIA, 2006, 49 (07) :1677-1685

[4]

Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights [J].

Chan, TF ;

Yuan, SSF ;

Chen, HS ;

Guu, CF ;

Wu, LC ;

Yeh, YT ;

Chung, YF ;

Jong, SB ;

Su, JH .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2004, 83 (02) :165-169

[5]

Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth [J].

Cianfarani, S ;

Martinez, C ;

Maiorana, A ;

Scirè, G ;

Spadoni, GL ;

Boemi, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (03) :1346-1351

[6]

Adiponectin expression in human fetal tissues during mid- and late gestation [J].

Corbetta, S ;

Bulfamante, G ;

Cortelazzi, D ;

Barresi, V ;

Cetin, I ;

Mantovani, G ;

Bondioni, S ;

Beck-Peccoz, P ;

Spada, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (04) :2397-2402

[7]

Reduced insulin sensitivity during growth hormone therapy for short children born small for gestational age [J].

Cutfield, WS ;

Jackson, WE ;

Jefferies, C ;

Robinson, EM ;

Breier, BH ;

Richards, GE ;

Hofman, PL .

JOURNAL OF PEDIATRICS, 2003, 142 (02) :113-116

[8]

Effects of growth hormone on growth, insulin resistance and related hormones (ghrelin, leptin and adiponectin) in Turner syndrome [J].

Darendeliler, Feyza ;

Aycan, Zehra ;

Cetinkaya, Ergun ;

Vidilisan, Sadi ;

Bas, Firdevs ;

Bideci, Aysun ;

Demirel, Fatma ;

Darcan, Sukran ;

Buyukgebiz, Atilla ;

Yildiz, Metin ;

Berberoglu, Merih ;

Arslanoglu, Ilknur ;

Bundak, Ruveyde .

HORMONE RESEARCH, 2007, 68 (01) :1-7

[9]

Diamond F, 2008, J PEDIATR ENDOCR MET, V21, P1133

[10]

Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty [J].

Donoso, M. A. ;

Munoz-Calvo, M. T. ;

Barrios, V. ;

Garrido, G. ;

Hawkins, F. ;

Argente, J. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2010, 162 (05) :905-911

← 1 2 3 4 5 6 7 8 →