The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata

被引:58
作者
Cotellessa, C [1 ]
Peris, K [1 ]
Caracciolo, E [1 ]
Mordenti, C [1 ]
Chimenti, S [1 ]
机构
[1] Univ Aquila, Dept Dermatol, I-67100 Laquila, Italy
关键词
D O I
10.1067/mjd.2001.109309
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Highly variable results of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata have been reported so far. Objective: The purposes of our study were to evaluate the efficacy and tolerability of DPCP in the treatment of chronic, extensive alopecia areata and to assess the long-term overall benefit of treatment. Methods: Fifty-six patients with chronic, extensive alopecia areata were enrolled in an open-label clinical trial. After sensitization with 2% DPCP, progressively higher concentrations beginning at 0.001% were applied weekly for 6 to 12 months to one side of the scalp. Results: Fifty-two of 56 patients completed therapy. Total regrowth of terminal hair was achieved in 25 of 52 patients (48%) at 6 months. The most frequent side effect was an eczematous reaction at the site of application. Notably, persistent response was observed in 60% of these patients after 6 to 18 months of follow-up (mean, 12 months). Conclusion: Topical DPCP treatment for alopecia areata is effective and well tolerated and provides prolonged therapeutic benefits.
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页码:73 / 76
页数:4
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