Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1)

被引：25

作者：

Fu, GH ^{[1
]}

Wang, Y

Xi, YH

Shen, WW

Pan, XY

Shen, WZ

Jiang, XS

Chen, GQ

机构：

[1] Shanghai Med Univ 2, Rui Jin Hosp, Shanghai Inst Hematol, Dept Pathophysiol, Shanghai 200025, Peoples R China

[2] Chinese Acad Prevent Med, Hlth Sci Ctr, Shanghai Inst Biol Sci, SSMU, Shanghai 200025, Peoples R China

[3] Harbin Med Univ, Dept Pathophysiol, Harbin 150086, Peoples R China

来源：

FEBS LETTERS | 2005年 / 579卷 / 10期

基金：

中国国家自然科学基金;

关键词：

anion exchanger; band; 3; p16; anion transport activity;

D O I：

10.1016/j.febslet.2005.02.063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By using the C-terminal 112-residue of band 3 to screen the K562 cDNA library, we find that the p16 interacts with band 3, which was confirmed both in yeast and in mammalian cells. Functional experiments show that p16 facilitates the movement of band 3 to plasma membrane with increased anion transport activity in 293t cells. Moreover, expression of endogenous p16 in 293t cells was increased at 24 and 36 h after transfection with band 3. Our findings provide a novel regulation pathway for both band 3 and p16. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：2105 / 2110

页数：6

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