Shaping the T-cell repertoire in the periphery

被引：11

作者：

Allen, Stacey ^{[1
]}

Turner, Stephen J. ^{[2
]}

Bourges, Dorothee ^{[1
]}

Gleeson, Paul A. ^{[1
]}

van Driel, Ian R. ^{[1
]}

机构：

[1] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2011年 / 89卷 / 01期

关键词：

T cell; immune tolerance; immune response; dendritic cells; Treg cells; CD103(+) DENDRITIC CELLS; GROWTH-FACTOR-BETA; PROMISCUOUS GENE-EXPRESSION; MYELIN BASIC-PROTEIN; IN-VIVO REQUIRES; TGF-BETA; SELF-TOLERANCE; INDOLEAMINE 2,3-DIOXYGENASE; CROSS-PRESENTATION; EPITHELIAL-CELLS;

D O I：

10.1038/icb.2010.133

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self-reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens. The implications of peripheral T-cell selection for the immune response as animals age are discussed as is the critical role of dendritic cells in directing T-cell differentiation. Immunology and Cell Biology (2011) 89, 60-69; doi:10.1038/icb.2010.133; published online 16 November 2010

引用

收藏

页码：60 / 69

页数：10

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