miLD and booLD programs for calculation and analysis of corrected linkage disequilibrium

被引：8

作者：

Aulchenko, YS

Axenovich, TI

Mackay, I

van Duijn, CM

机构：

[1] Erasmus Med Ctr, Dept Epidemiol & Biostat, Genet Epidemiol Unit, NL-3000 DR Rotterdam, Netherlands

[2] RAS, SD, Inst Cytol & Genet, Novosibirsk, Russia

[3] Oxagen Ltd, Dept Bioinformat, Abingdon, Oxon, England

来源：

ANNALS OF HUMAN GENETICS | 2003年 / 67卷

关键词：

D O I：

10.1046/j.1469-1809.2003.00041.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We describe software which calculates a set of linkage disequilibrium statistics, including multiallelic D' corrected by the bootstrap and permutation. The software also provides a tool for maximum likelihood and least squares estimation and testing of a set of hierarchical hypotheses formulated within the framework of the Malecot model of the decay of linkage disequilibrium with distance. Additionally, the bootstrap approach is used for estimation of the model parameter's confidence intervals and for hypothesis testing. The programs are available from http://www.geneticepi.com/Research/software/software.html.

引用

页码：372 / 375

页数：4

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