Endothelial cell dysfunction: can't live with it, how to live without it

被引：83

作者：

Goligorsky, MS

机构：

[1] New York Med Coll, Renal Inst, Dept Med, Valhalla, NY 10595 USA

[2] New York Med Coll, Renal Inst, Dept Pharmacol, Valhalla, NY 10595 USA

[3] New York Med Coll, Div Nephrol, Valhalla, NY 10595 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2005年 / 288卷 / 05期

关键词：

uncoupled endothelial nitric oxide synthase; oxidative stress; vascular wall; atherogenesis;

D O I：

10.1152/ajprenal.00333.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Endothelial cell dysfunction is emerging as an ultimate culprit for diverse cardiovascular diseases and cardiovascular complications of chronic renal diseases, yet the definition of this new syndrome, its pathophysiology, and therapy remain poorly defined. Here, I summarize some molecular mechanisms leading from hyperhomocystinemia, elevated asymmetric dimethylarginine, and advanced glycolation end product-modified protein level to the proatherogenic, prothrombogenic, and proinflammatory endothelial phenotype and offer a model of endothelial dysfunction based on the interconnectedness of diverse functions. Finally, several therapeutic strategies to prevent and correct endothelial dysfunction are discussed in the light of uncertainty of their action modulated by the endothelial dysfunction per se.

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收藏

页码：F871 / F880

页数：10

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