β-Blockers and bone health

被引：19

作者：

Hofbauer, Lorenz C. ^{[1
,2
,3
]}

Henneicke, Holger ^{[1
,2
,3
]}

机构：

[1] Tech Univ Dresden, Dept Med 3, Dresden, Germany

[2] Tech Univ Dresden, Ctr Hlth Aging, Dresden, Germany

[3] Tech Univ Dresden, Ctr Regenerat Therapies Dresden, Dresden, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2018年 / 128卷 / 11期

关键词：

SYMPATHETIC-NERVOUS-SYSTEM; PROPRANOLOL; TURNOVER; WOMEN; MASS; RATS;

D O I：

10.1172/JCI122992

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Bone metabolism is controlled by endocrine, paracrine, and inflammatory signals that continuously operate in health and disease. While these signals are critical for skeletal adaptation during development, longitudinal growth, and repair, disturbances such as sex hormone deficiency or chronic inflammation have unambiguously been linked to bone loss and skeletal fragility across species. In the current issue of the JCI, Khosla et al. evaluated the role of sympathetic outflow and present evidence to support the idea that the sympathetic nervous system regulates bone metabolism in humans, primarily via the beta(1)-adrenergic receptor.

引用

收藏

页码：4745 / 4747

页数：3

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