Distribution of orexin receptor mRNA in the rat brain

被引：825

作者：

Trivedi, P ^{[1
]}

Yu, H ^{[1
]}

MacNeil, DJ ^{[1
]}

Van der Ploeg, LHT ^{[1
]}

Guan, XM ^{[1
]}

机构：

[1] Merck Res Labs, Dept Obes Res, Rahway, NJ 07065 USA

来源：

FEBS LETTERS | 1998年 / 438卷 / 1-2期

关键词：

orexin; G-protein coupled receptor; feeding; in situ hybridization;

D O I：

10.1016/S0014-5793(98)01266-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression pattern of mRNA encoding two orexin receptors (OX1R and OX2R) in the rat brain was examined. OX1R and OX2R exhibited marked differential distribution. Within the hypothalamus, OX1R mRNA is most abundant in the ventromedial hypothalamic nucleus whereas OX2R is predominantly expressed in the paraventricular nucleus, High levels of OX1R mRNA were also detected in tenia tecta, the hippocampal formation, dorsal raphe, and locus coeruleus, OX2R mRNA is mainly expressed in cerebral cortex, nucleus accumbens, subthalamic and paraventricular thalamic nuclei, anterior pretectal nucleus. The presence of orexin receptor mRNA in the hypothalamus is in support of its proposed role in feeding regulation, Broad central distribution of orexin receptors may indicate additional functions for orexins, (C) 1998 Federation of European Biochemical Societies.

引用

页码：71 / 75

页数：5

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