Next-generation HydroGel films as tissue sealants and adhesion barriers

被引:59
作者
Bennett, SL
Melanson, DA
Torchiana, DF
Wiseman, DM
Sawhney, AS
机构
[1] Confluent Surg Inc, Waltham, MA 02451 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA
关键词
D O I
10.1046/j.0886-0440.2003.00303.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. The development of conveniently sprayed, tissue-adherent, inert hydrogel films has made possible the creation of novel products that can serve a dual function, as a surgical sealant to achieve immediate hemostasis, and as a barrier to prevent adhesion formation over time. Methods: A sprayable, in situ formed absorbable hydrogel film was evaluated as a tissue sealant in a heparinized canine carotid artery graft model. PTFE grafts with leaking end-to-side anastomoses were treated with the synthetic sealant, and hemostasis was evaluated upon restoration of blood flow. Also, the hydrogel films were evaluated as an adhesion barrier in a rabbit pericardial abrasion model. Results: The sprayable, in situ forming hydrogel film was shown to immediately seal carotid-PTFE anastomoses in six of six applications. Hydrogel application in a rabbit pericardial abrasion model resulted in a statistically significant reduction in the number and tenacity of adhesions. Conclusions: This novel in situ formed sprayable hydrogel film has demonstrated a dual function as an effective tissue sealant and as an adhesion barrier in cardiovascular preclinical models. These next generation synthetic biomaterials are currently undergoing clinical investigations.
引用
收藏
页码:494 / 499
页数:6
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