Cooperativity of adaptive and innate immunity: implications for cancer therapy

被引：38

作者：

Shanker, Anil ^{[1
,2
]}

Marincola, Francesco M. ^{[3
,4
]}

机构：

[1] Meharry Med Coll, Sch Med, Lab Lymphocyte Funct, Dept Biochem & Canc Biol, Nashville, TN 37208 USA

[2] Vanderbilt Univ, Dept Canc Biol, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

[3] NIH, IDIS, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA

[4] NIH, Trans NIH Ctr Human Immunol CHI, Bethesda, MD 20892 USA

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2011年 / 60卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Innate immunity; Adaptive T cells; Natural killer cells; Effector function; Immune regulation; Cancer immunotherapy; CD8(+) T-CELLS; TUMOR-NECROSIS-FACTOR; GENE-SPECIFIC CONTROL; DENDRITIC CELLS; IN-VIVO; ADIPOSE-TISSUE; ANTIBACTERIAL DEFENSE; INTERFERON-GAMMA; UP-REGULATION; CROSS-TALK;

D O I：

10.1007/s00262-011-1053-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The dichotomy of immunology into innate and adaptive immunity has created conceptual barriers in appreciating the intrinsic two-way interaction between immune cells. An emerging body of evidence in various models of immune rejection, including cancer, indicates an indispensable regulation of innate effector functions by adaptive immune cells. This bidirectional cooperativity in innate and adaptive immune functions has broad implications for immune responses in general and for regulating the tumor-associated inflammation that overrides the protective antitumor immunity. Mechanistic understanding of this two-way immune cross-talk could provide insights into novel strategies for designing better immunotherapy approaches against cancer and other diseases that normally defy immune control.

引用

收藏

页码：1061 / 1074

页数：14

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