Cholesterol and the biology of Alzheimer's disease

被引：220

作者：

Wolozin, B ^{[1
]}

机构：

[1] Loyola Univ, Med Ctr, Dept Pharmacol, Maywood, IL 60153 USA

来源：

NEURON | 2004年 / 41卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(03)00840-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and the toxic peptide generated by its cleavage, beta-amyloid (Abeta). The ability of cholesterol to modulate Abeta production suggests opportunities for therapeutic intervention, although the functional significance underlying the connection between cholesterol and Abeta remains to be investigated.

引用

页码：7 / 10

页数：4

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