Autoimmune diseases: genes, bugs and failed regulation

被引:130
作者
Ermann, J [1 ]
Fathman, CG [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA
关键词
D O I
10.1038/ni0901-759
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this Overview, common themes of the accompanying News & Views on RA, SLE, IDDM, thyroiditis and MS are discussed. A unifying concept for the development of these and other autoimmune diseases should incorporate genetic predisposition, environmental factors and immune dysregulation.
引用
收藏
页码:759 / 761
页数:3
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共 17 条
  • [1] Pathogenesis of arthritis: recent research progress
    Feldmann, M
    [J]. NATURE IMMUNOLOGY, 2001, 2 (09) : 771 - 773
  • [2] B-cell epitope spreading in autoimmunity
    James, JA
    Harley, JB
    [J]. IMMUNOLOGICAL REVIEWS, 1998, 164 : 185 - 200
  • [3] Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity
    Lipsky, PE
    [J]. NATURE IMMUNOLOGY, 2001, 2 (09) : 764 - 766
  • [4] Regulatory T cells in the control of immune pathology
    Maloy, KJ
    Powrie, F
    [J]. NATURE IMMUNOLOGY, 2001, 2 (09) : 816 - 822
  • [5] Epistatic modifiers of autoimmunity in a murine model of lupus nephritis
    Morel, L
    Tian, XH
    Croker, BP
    Wakeland, EK
    [J]. IMMUNITY, 1999, 11 (02) : 131 - 139
  • [6] Genetic models of abnormal apoptosis in lymphocytes
    Refaeli, Y
    Van Parijs, L
    Abbas, AK
    [J]. IMMUNOLOGICAL REVIEWS, 1999, 169 : 273 - 282
  • [7] Immunology -: A new look at MHC and autoimmune disease
    Ridgway, WM
    Fassò, M
    Fathman, CG
    [J]. SCIENCE, 1999, 284 (5415) : 749 - +
  • [8] Certified professionals:: CD4+CD25+ suppressor T cells
    Shevach, EM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (11) : F41 - F45
  • [9] Autoimmune mechanisms in antibiotic treatment-resistant Lyme arthritis
    Steere, AC
    Gross, D
    Meyer, AL
    Huber, BT
    [J]. JOURNAL OF AUTOIMMUNITY, 2001, 16 (03) : 263 - 268
  • [10] Multiple sclerosis: a two-stage disease
    Steinman, L
    [J]. NATURE IMMUNOLOGY, 2001, 2 (09) : 762 - 764