Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

被引：276

作者：

Horton, JD ^{[1
]}

Shimomura, I ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1999年 / 10卷 / 02期

关键词：

D O I：

10.1097/00041433-199904000-00008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes. Curr Opin Lipidol 10:143-150, (C) 1999 Lippincott Williams & Wilkins.

引用

页码：143 / 150

页数：8

共 36 条

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