Emulsions and microemulsions with a fluorocarbon phase

被引:67
作者
Krafft, MP
Chittofrati, A
Riess, JG
机构
[1] CNRS, Inst Charles Sadron, F-67083 Strasbourg, France
[2] Solvay Solexis, I-20021 Milan, Italy
[3] Univ Calif San Diego, MRI Inst, San Diego, CA 92103 USA
关键词
perfluorocarbon; emulsion; microemulsion; reverse emulsion; oxygen delivery; targeted emulsion; diagnosis; drug delivery; polymerization;
D O I
10.1016/S1359-0294(03)00045-1
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A phase III clinical study of a perfluorooctyl bromide emulsion demonstrated reduction and avoidance of donor blood transfusion in surgery. Novel fluorocarbon-in-water emulsions are being investigated, including emulsions highly stabilized by fluorocarbon-hydrocarbon diblocks and targeted emulsions for molecular imaging, diagnosis and drug delivery. Reverse water-influorocarbon emulsions and microemulsions that have potential for pulmonary drug delivery are also being studied. Microemulsions with highly fluorinated components are being actively investigated, with applications in polymerization technology and as research tools. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:251 / 258
页数:8
相关论文
共 83 条
[1]  
Anderson SA, 2000, MAGNET RESON MED, V44, P433, DOI 10.1002/1522-2594(200009)44:3<433::AID-MRM14>3.0.CO
[2]  
2-9
[3]  
[Anonymous], 1999, HDB MICROEMULSION SC
[4]   Free radical controlled polymerization of fluorinated copolymers produced in microemulsion [J].
Apostolo, M ;
Arcella, V ;
Storti, G ;
Morbidelli, M .
MACROMOLECULES, 2002, 35 (16) :6154-6166
[5]  
AUDONNET S, 2002, 4 INT S CURR ISS BLO, P60
[6]   Highly concentrated emulsions:: Physicochemical principles of formulation [J].
Babak, VG ;
Stébé, MJ .
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2002, 23 (1-3) :1-22
[7]   The pH-dependent surface activity of a hydrocarbon/fluorocarbon catanionic surfactant for water/hydrofluoroether microemulsions: The characterization of a new acid/soap complex [J].
Baran, JR ;
Decker, EL ;
Wilcox, HN .
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2002, 23 (1-3) :23-28
[8]   Winsor I↔ III↔II microemulsion phase behavior of hydrofluoroethers and fluorocarbon/hydrocarbon catanionic surfactants [J].
Baran, JR .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2001, 234 (01) :117-121
[9]  
BERTILLA SM, 2003, IN PRESS LANGMUIR
[10]   Immunological aspects of blood transfusions [J].
Brand, A .
TRANSPLANT IMMUNOLOGY, 2002, 10 (2-3) :183-190