Aurin tricarboxylic acid inhibits adhesion of platelets to subendothelium

被引：9

作者：

Owens, MR

Holme, S

机构：

[1] Hematol. Oncol. Consult. Tidewater, Amer. Red Cross, Mid-Atlantic Region, Norfolk, VA

[2] Hematol. Oncol. Consult. Tidewater, Norfolk, VA 23510

来源：

THROMBOSIS RESEARCH | 1996年 / 81卷 / 02期

关键词：

platelet aggregation; platelet adhesion; aurin tricarboxylic acid; subendothelium; von Willebrand's factor; thrombin;

D O I：

10.1016/0049-3848(95)00234-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aurin-tricarboxylic acid (ATA) is a polycarboxylated compound which binds to high molecular weight multimers of von Willebrand factor (vWf), effectively preventing binding of vWf to platelet membrane GPIb. By this mechanism, ATA inhibits shear-induced platelet aggregation as well as ristocetin-induced platelet aggregation/agglutination, both of which require interaction of platelets and vWf. Although it is reasonable to assume that ATA might also interfere with platelet adhesion, the effects of ATA on this aspect of platelet function have not been described.

引用

页码：177 / 185

页数：9

共 24 条

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