Artificial diiron proteins: From structure to function

被引：69

作者：

Calhoun, JR

Nastri, F

Maglio, O

Pavone, V

Lombardi, A

DeGrado, WF

机构：

[1] Univ Naples Federico II, Dept Chem, I-80126 Naples, Italy

[2] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

来源：

BIOPOLYMERS | 2005年 / 80卷 / 2-3期

关键词：

de novo protein design; computional protein design; metalloprotein; diiron protein; structure;

D O I：

10.1002/bip.20230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

De novo protein design provides an attractive approach,for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins. (c) 2005 Wiley Periodicals, Inc.

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页码：264 / 278

页数：15

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