OXA-51-like β-lactamases and their association with particular epidemic lineages of Acinetobacter baumannii

被引：88

作者：

Evans, B. A. ^{[1
]}

Hamouda, A. ^{[1
]}

Towner, K. J. ^{[2
]}

Amyes, S. G. B. ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Infect Dis, Edinburgh EH16 4SB, Midlothian, Scotland

[2] Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Dept Clin Microbiol, Nottingham, England

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2008年 / 14卷 / 03期

基金：

英国医学研究理事会;

关键词：

Acinetobacter baumannii; bla(OXA-51-like); carbapenemase; lineages; linkage map; sequence groups;

D O I：

10.1111/j.1469-0691.2007.01919.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Sixty diverse clinical Acinetobacter baumannii isolates of worldwide origin were assigned to sequence groups, based on a multiplex PCR for the ompA, csuE and bla(OXA-51-like) genes. The majority (77%) of isolates belonged to sequence groups 1 and 2 (SG1 and SG2), with sequence group 3 (SG3) and non-grouped isolates accounting for the remainder. The isolates were not closely related according to pulsed-field gel electrophoresis (PFGE), and the majority were sensitive to imipenem and meropenem. The construction of a linkage map of OXA-51-like beta-lactamase sequence relationships revealed two closely related clusters of enzymes, one focused around OXA-66 and the other around OXA-69. Isolates belonging to SG1 encoded an enzyme from the OXA-66 cluster, while those belonging to SG2 encoded an enzyme from the OXA-69 cluster. All SG3 isolates encoded OXA-71, which does not form part of a close enzyme grouping. Major multinational lineages accounted for a significant proportion of A. baumannii clinical isolates, and the evolution of the OXA-51-like enzymes appears to be an ongoing process.

引用

页码：268 / 275

页数：8

共 26 条

[1] BSAC standardized disc susceptibility testing method (version 6) [J].

Andrews, J. M. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (01) :20-41

[2]

[Anonymous], 1991, J Antimicrob Chemother, V27 Suppl D, P1

[3] Acinetobacter spp, as nosocomial pathogens: Microbiological, clinical, and epidemiological features [J].

BergogneBerezin, E ;

Towner, KJ .

CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (02) :148-+

[4] The sequences of seven class D β-lactamases isolated from carbapenem-resistant Acinetobacter baumannii from four continents [J].

Brown, S ;

Amyes, SGB .

CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (04) :326-329

[5] Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina [J].

Brown, S ;

Young, HK ;

Amyes, SGB .

CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (01) :15-23

[6] OXA β-lactamases in Acinetobacter:: the story so far [J].

Brown, S ;

Amyes, S .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 57 (01) :1-3

[7] Identification of widespread, closely related Acinetobacter baumannii isolates in Portugal as a subgroup of European clone II [J].

Da Silva, G. ;

Dijkshoorn, L. ;

van der Reijden, T. ;

van Strijen, B. ;

Duarte, A. .

CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (02) :190-195

[8] Comparison of outbreak and nonoutbreak Acinetobacter baumannii strains by genotypic and phenotypic methods [J].

Dijkshoorn, L ;

Aucken, H ;

GernerSmidt, P ;

Janssen, P ;

Kaufmann, ME ;

Garaizar, J ;

Ursing, J ;

Pitt, TL .

JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (06) :1519-1525

[9] Acinetobacter species identification by using tRNA spacer fingerprinting [J].

Ehrenstein, B ;

Bernards, AT ;

Dijkshoorn, L ;

GernerSmidt, P ;

Towner, KJ ;

Bouvet, PJM ;

Daschner, FD ;

Grundmann, H .

JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (10) :2414-2420

[10] Eleven novel OXA-51-like enzymes from clinical isolates of Acinetobacter baumannii [J].

Evans, B. A. ;

Brown, S. ;

Hamouda, A. ;

Findlay, J. ;

Amyes, S. G. B. .

CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (11) :1137-1138

← 1 2 3 →