Neurocognitive and Neuroimaging Predictors of Clinical Outcome in Bipolar Disorder

被引:35
作者
Bearden, Carrie E. [3 ,4 ]
Woogen, Michelle [2 ]
Glahn, David C. [1 ,2 ]
机构
[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
[2] Olin Neuropsychiat Res Ctr, Inst Living, Hartford, CT 06106 USA
[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
关键词
Bipolar disorder; Neuropsychology; Neuroanatomy; Functional neuroimaging; Outcome; Disability; EUTHYMIC PATIENTS; 1ST-DEGREE RELATIVES; COGNITIVE IMPAIRMENT; I DISORDER; SCHIZOPHRENIA; METAANALYSIS; DEFICITS; ENDOPHENOTYPES; ABNORMALITIES; NEUROANATOMY;
D O I
10.1007/s11920-010-0151-5
中图分类号
R749 [精神病学];
学科分类号
100204 [神经病学];
摘要
Historically, bipolar disorder has been conceptualized as a disease involving episodic rather than chronic dysfunction. However, increasing evidence indicates that bipolar disorder is associated with substantial inter-episode psychosocial and vocational impairment. Here we review the contributions of neurocognitive deficits and structural and functional neuroanatomic alterations to the observed functional impairments. In particular, compelling evidence now suggests that neurocognitive impairments, particularly in the areas of attention, processing speed, and memory, are associated with functional outcome. Although investigation of the neural correlates of functional disability in bipolar disorder is only in its nascent stages, preliminary evidence suggests that white matter abnormalities may be predictive of poor outcome. A better understanding of the relationship between neurocognitive and neuroimaging assays and functional outcome has the potential to improve current treatment options and provide targets for new treatment strategies in bipolar disorder.
引用
收藏
页码:499 / 504
页数:6
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