Targeting transcription to the neuromuscular synapse

被引：174

作者：

Schaeffer, L ^{[1
]}

d'Exaerde, AD ^{[1
]}

Changeux, JP ^{[1
]}

机构：

[1] Inst Pasteur, Mol Neurobiol Lab, CNRS, URA Recepteurs & Cognit 2182, F-75724 Paris 15, France

来源：

NEURON | 2001年 / 31卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(01)00353-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Concomitant with innervation, genes coding for components of the neuromuscular junction become exclusively expressed in subsynaptic nuclei. A six-base pair element, the N box, can confer synapse-specific transcription to the acetylcholine nicotinic receptor delta and epsilon subunit, utrophin, and acetylcholine esterase genes. N box-dependent synaptic expression is stimulated by the nerve-derived signal agrin and the trophic factor neuregulin, which triggers the MAPK and JNK signaling pathways, to ultimately allow activation by the N box binding Ets transcription factor GABP.

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收藏

页码：15 / 22

页数：8

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