Farnesoid X receptor: From structure to potential clinical applications

被引:119
作者
Pellicciari, R
Costantino, G
Fiorucci, S
机构
[1] Univ Perugia, Dipartimento Chim & tecnol Farmaco, I-06123 Perugia, Italy
[2] Univ Perugia, Dipartimento Med Clin & Sperimentale, I-06122 Perugia, Italy
关键词
D O I
10.1021/jm0582221
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:5383 / 5403
页数:21
相关论文
共 120 条
[1]   Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative [J].
Adachi, R ;
Honma, Y ;
Masuno, H ;
Kawana, K ;
Shimomura, L ;
Yamada, S ;
Makishima, M .
JOURNAL OF LIPID RESEARCH, 2005, 46 (01) :46-57
[2]  
Agellon LB, 1997, BIOCHEM J, V328, P393
[3]   Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor [J].
Ananthanarayanan, M ;
Balasubramanian, N ;
Makishima, M ;
Mangelsdorf, DJ ;
Suchy, FJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) :28857-28865
[4]   Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor [J].
Anisfeld, AM ;
Kast-Woelbern, HR ;
Meyer, ME ;
Jones, SA ;
Zhang, YQ ;
Williams, KJ ;
Willson, T ;
Edwards, PA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (22) :20420-20428
[5]  
ARANDA A, 2001, PHARMACOL REV, V83, P1269
[6]   FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity [J].
Barbier, O ;
Torra, IP ;
Sirvent, A ;
Claudel, T ;
Blanquart, C ;
Duran-Sandoval, D ;
Kuipers, F ;
Kosykh, V ;
Fruchart, JC ;
Staels, B .
GASTROENTEROLOGY, 2003, 124 (07) :1926-1940
[7]  
BAUER U, 2003, Patent No. 016280
[8]  
Bauer U., 2003, WO Pat, Patent No. [WO2003015771A1, 2003015771]
[9]   FXR as a novel therapeutic target for vascular disease [J].
Bishop-Bailey, D .
DRUG NEWS & PERSPECTIVES, 2004, 17 (08) :499-504
[10]   Expression and activation of the farnesoid X receptor in the vasculature [J].
Bishop-Bailey, D ;
Walsh, DT ;
Warner, TD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (10) :3668-3673