Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp .2. Structure elucidation of chloropeptin I

被引：49

作者：

Matsuzaki, K

Ogino, T

Sunazuka, T

Tanaka, H

Omura, S

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 01期

关键词：

D O I：

10.7164/antibiotics.50.66

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by H-1 and C-13 NMR experiments and chemical degradation. It is a peptide antibiotic consisting of six aryl amino acids residues and an a-ore aryl acid some of which have chlorine atoms.

引用

页码：66 / 69

页数：4

共 6 条

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