Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease

被引：23

作者：

Armentero, M. T. ^{[1
]}

Levandis, G. ^{[1
]}

Bramanti, P. ^{[3
]}

Nappi, G. ^{[1
,2
]}

Blandini, F. ^{[1
]}

机构：

[1] Univ Pavia, Neurol Inst C Mondino, IRCCS, Interdepartmental Res Ctr Parkinsons Dis CRIMP, I-27100 Pavia, Italy

[2] Univ Roma La Sapienza, Dept Neurol & Otorhinolaryngol, Rome, Italy

[3] Ctr Neurol Bonino Pulejo, IRCCS, Messina, Italy

来源：

EXPERIMENTAL NEUROLOGY | 2008年 / 212卷 / 02期

关键词：

D O I：

10.1016/j.expneurol.2008.04.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic reduction of the caloric intake is associated with extended lifespan, in rodents, and has been proposed to counteract neuronal loss in animal models of neurodegeneration. To test this hypothesis, we investigated the effect of dietary restriction (DR) in 2 rodent model of Parkinson's disease, based on the intrastriatal infusion of 6-hydroxydopamine. We could not confirm the neuroprotective effect of DR previously suggested: histological and behavioral measures indicated similar degrees of dopaminergic neuron loss in rats maintained oil DR - for two or eight weeks prior to the lesion - or with free access to food. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：548 / 551

页数：4

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