Organic reactions in ionic liquids: N-alkylation of phthalimide and several nitrogen heterocycles

被引：67

作者：

Le, ZG

Chen, ZC ^{[1
]}

Hu, Y

Zheng, QG

机构：

[1] Zhejiang Univ, Ningbo Inst Technol, Ningbo 315100, Peoples R China

[2] Aston Univ, Pharmaceut Sci Res Inst, Birmingham B4 TET, W Midlands, England

[3] E China Inst Technol, Dept Appl Chem, Fuzhou 344000, Peoples R China

[4] Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2004年 / 02期

关键词：

ionic liquids; N-alkylation; phthalimide; heterocycle;

D O I：

10.1055/s-2003-44383

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Alkylation of heterocyclic compounds bearing an acidic hydrogen atom attached to nitrogen with alkyl halides is accomplished in ionic liquids ([bmim]BF4 = 1-butyl-3-methylimidazolium tetrafluoroborate, [bmim]PF6 = 1-butyl-3-methylimidazolium hexafluorophosphate, [buPy]BF4 = butylpyridinium tetrafluoroborate) in the presence of potassium hydroxide as a base. In this manner, phthalimide, indole, benzimidazole, succinimide can be successfully alkylated. The procedure is convenient, efficient, and generally affords the N-alkylated product exclusively.

引用

页码：208 / 212

页数：5

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