Actions of estrogens on glial cells: Implications for neuroprotection

被引：158

作者：

Arevalo, Maria-Angeles ^{[1
]}

Santos-Galindo, Maria ^{[1
]}

Bellini, Maria-Jose ^{[1
]}

Azcoitia, Inigo ^{[2
]}

Garcia-Segura, Luis M. ^{[1
]}

机构：

[1] CSIC, Inst Cajal, E-28002 Madrid, Spain

[2] Univ Complutense Madrid, Fac Biol, Dept Biol Celular, E-28040 Madrid, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2010年 / 1800卷 / 10期

关键词：

Astroglia; Estradiol; Microglia; Myelin; Oligodendroglia; Selective estrogen receptor modulator; FIBRILLARY ACIDIC PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GONADAL HORMONE REGULATION; RECEPTOR MODULATORS SERMS; HEAT-SHOCK PROTEINS; GROWTH-FACTOR-ALPHA; REACTIVE ASTROCYTES; GENE-EXPRESSION; SEX STEROIDS; IN-VIVO;

D O I：

10.1016/j.bbagen.2009.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Glial cells are directly or indirectly affected by estradiol and by different estrogenic compounds, such as selective estrogen receptor modulators. Acting on oligodendrocytes, astrocytes and microglia, estrogens regulate remyelination, edema formation, extracellular glutamate levels and the inflammatory response after brain injury. In addition, estradiol induces the expression and release of growth factors by glial cells that promote neuronal survival. Therefore, glial cells are important players in the neuroprotective and reparative mechanisms of estrogenic compounds. (C) 2009 Elsevier B.V. All rights reserved.

引用

收藏

页码：1106 / 1112

页数：7

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