The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke

被引:54
作者
Carlsson, M
Orho-Melander, M
Hedenbro, J
Almgren, P
Groop, LC
机构
[1] Malmo Univ Hosp, Dept Endocrinol, S-20502 Malmo, Sweden
[2] Lund Univ, Univ Lund Hosp, Dept Surg, S-22185 Lund, Sweden
关键词
D O I
10.1210/jc.85.8.2801
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To test the hypothesis that the APT polymorphism of the fatty acid-binding protein 2 gene (FABP2) is associated with impaired lipid metabolism and cardiovascular disease, we compared clinical characteristics and a parental history of cardiovascular disease between 213 sibling pairs discordant for the polymorphism. Siblings with an excess of the T54 allele had higher triglyceride (P = 0.002) and cholesterol (P = 0.019) concentrations than siblings with the A54 allele. Parents of offspring with the T54T and T54A genotypes reported an increased prevalence of stroke compared to parents of offspring with the A54A genotype (P = 0.007). In summary, we have confirmed the association of the FABP2 T54 allele with increased concentrations of cholesterol and triglycerides in genotype-discordant sibling pairs. We also present novel evidence that genetic variation in the FABP2 gene may increase susceptibility to stroke.
引用
收藏
页码:2801 / 2804
页数:4
相关论文
共 33 条
[1]   Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene [J].
Ågren, JJ ;
Valve, R ;
Vidgren, H ;
Laakso, M ;
Uusitupa, M .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (10) :1606-1610
[2]  
[Anonymous], 1990, CHOLESTEROL ATHEROSC
[3]   AN AMINO-ACID SUBSTITUTION IN THE HUMAN INTESTINAL FATTY-ACID-BINDING PROTEIN IS ASSOCIATED WITH INCREASED FATTY-ACID-BINDING, INCREASED FAT OXIDATION, AND INSULIN-RESISTANCE [J].
BAIER, LJ ;
SACCHETTINI, JC ;
KNOWLER, WC ;
EADS, J ;
PAOLISSO, G ;
TATARANNI, PA ;
MOCHIZUKI, H ;
BENNETT, PH ;
BOGARDUS, C ;
PROCHAZKA, M .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (03) :1281-1287
[4]   A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells [J].
Baier, LJ ;
Bogardus, C ;
Sacchettini, JC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (18) :10892-10896
[5]  
BYRNE CD, 1994, DIABETOLOGIA, V37, P889, DOI 10.1007/BF00400944
[6]   RESISTANCE TO INSULIN SUPPRESSION OF PLASMA-FREE FATTY-ACID CONCENTRATIONS AND INSULIN STIMULATION OF GLUCOSE-UPTAKE IN NONINSULIN-DEPENDENT DIABETES-MELLITUS [J].
CHEN, YDI ;
GOLAY, A ;
SWISLOCKI, ALM ;
REAVEN, GM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (01) :17-21
[7]   USE OF TRANSGENIC MICE TO MAP CIS-ACTING ELEMENTS IN THE INTESTINAL FATTY-ACID BINDING-PROTEIN GENE (FABPI) THAT CONTROL ITS CELL LINEAGE-SPECIFIC AND REGIONAL PATTERNS OF EXPRESSION ALONG THE DUODENAL COLONIC AND CRYPT VILLUS AXES OF THE GUT EPITHELIUM [J].
COHN, SM ;
SIMON, TC ;
ROTH, KA ;
BIRKENMEIER, EH ;
GORDON, JI .
JOURNAL OF CELL BIOLOGY, 1992, 119 (01) :27-44
[8]   Use of siblings as controls in case-control association studies [J].
Curtis, D .
ANNALS OF HUMAN GENETICS, 1997, 61 :319-333
[9]  
FERRANNINI E, 1983, J CLIN INVEST, V72, P1737, DOI 10.1172/JCI111133
[10]   AMBIENT PLASMA-FREE FATTY-ACID CONCENTRATIONS IN NONINSULIN-DEPENDENT DIABETES-MELLITUS - EVIDENCE FOR INSULIN RESISTANCE [J].
FRAZE, E ;
DONNER, CC ;
SWISLOCKI, ALM ;
CHIOU, YAM ;
CHEN, YDI ;
REAVEN, GM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (05) :807-811