MN1, a novel player in human AML

被引：31

作者：

Grosveld, Gerard C. ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Genet & Tumor Cell Biol, Memphis, TN 38105 USA

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2007年 / 39卷 / 03期

关键词：

myeloid leukemia; transcription coactivator; CBF leukemia;

D O I：

10.1016/j.bcmd.2007.06.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The transcriptional coactivator MN1 has been identified as a gene overexpressed in certain types of human acute myeloid leukemia. Upregulation is invariantly associated with inv(16) AML but is also found in other AML subtypes. Overexpression of this gene is also associated with a worse prognosis and a shorter survival in AML patients with a normal karyotype. In this short review, I will discuss the role of MN1 in myeloid leukemia. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：336 / 339

页数：4

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