Hsp90-binding immunophilins in plants: the protein movers

被引：83

作者：

Pratt, WB ^{[1
]}

Krishna, P

Olsen, LJ

机构：

[1] Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA

[2] Univ Western Ontario, Dept Plant Sci, London, ON N6A 5B7, Canada

[3] Univ Michigan, Dept Biol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN PLANT SCIENCE | 2001年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1360-1385(00)01843-4

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Studies of cytoplasmic-nuclear trafficking of the glucocorticoid receptor in mammalian cells suggest that the hsp90/hsp70-based chaperone system and the hsp90-binding immunophilin FKBP52 are involved in targeted movement of the receptor along microtubule tracts. Over the past few years, plant cells have been found to possess a similar multiprotein chaperone machinery. Plant cells also contain high molecular weight FKBPs that bind to plant hsp90 via a conserved protein interaction involving tetratricopeptide repeat domains. The hsp90/hsp70-based machinery and the plant FKBPs might be used to target the trafficking of signalling proteins in plants.

引用

页码：54 / 58

页数：5

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