Design and synthesis of conformationally-constrained MMP inhibitors

被引：37

作者：

Natchus, MG

Cheng, MY

Wahl, CT

Pikul, S

Almstead, NG

Bradley, RS

Taiwo, YO

Mieling, GE

Dunaway, CM

Snider, CE

McIver, JM

Barnett, BL

McPhail, SJ

Anastasio, MB

De, B

机构：

[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

[2] Procter & Gamble Co, Miami Valley Labs, Corp Res Div, Cincinnati, OH 45253 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(98)00370-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2077 / 2080

页数：4

共 20 条

[1]

[Anonymous], 1984, ASYMMETRIC SYNTHESIS

[2] Molecular recognition of protein-ligand complexes: Applications to drug design [J].