Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

被引：241

作者：

Engblom, D

Saha, S

Engström, L

Westman, M

Audoly, LP

Jakobsson, PJ

Blomqvist, A ^{[1
]}

机构：

[1] Linkoping Univ, Fac Hlth Sci, Div Cell Biol, S-58185 Linkoping, Sweden

[2] Karolinska Inst, Ctr Struct Biochem, S-14157 Huddinge, Sweden

[3] Karolinska Inst, Dept Biochem & Biophys, S-17177 Stockholm, Sweden

[4] Pfizer Inc, Global Res & Dev, Groton Labs, Inflammat Unit, Groton, CT 06340 USA

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 11期

关键词：

D O I：

10.1038/nn1137

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E-2 synthesis after peripheral injection of bacterial-wall lipopolysaccharide, but their pyretic capacity in response to centrally administered PGE(2) was intact. Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE(2)-dependent acute phase reactions elicited by the brain.

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页码：1137 / 1138

页数：2

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