Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory

被引：27

作者：

Bando, T

Sekine, K

Kobayashi, S

Watabe, AM

Rump, A

Tanaka, M

Suda, Y

Kato, S

Morikawa, Y

Manabe, T

Miyajima, A ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular, Lab Cell Growth & Differentiat, Bunkyo Ku, Tokyo 1130032, Japan

[2] Univ Tokyo, Inst Mol & Cellular, Lab Neuclear Signaling, Bunkyo Ku, Tokyo 1130032, Japan

[3] Univ Tokyo, Inst Mol & Cellular, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Basic Med Sci, Div Neuronal Network, Tokyo 1088639, Japan

[5] Wakayama Med Coll, Dept Anat & Neurobiol, Wakayama 6418509, Japan

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2005年 / 25卷 / 10期

关键词：

D O I：

10.1128/MCB.25.10.4166-4175.2005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuronal leucine-rich repeat proteins (NLRRs) are type I transmembrane proteins and expressed in neuronal tissues, but their function remains unknown. Here, we describe the identification and characterization of a new member of the NLRR family, NLRR4, and its potential role in long-lasting memory. We generated NLRR4-deficient (NLRR4(-/-)) mice and found that they showed impaired memory retention. In hippocampus-dependent learning tasks, NLRR4(-/-) mice were able to learn and maintain the memories for one day but unable to retain the memories for four days after learning. In contrast, in a hippocampus-independent task, NLRR4(-/-) mice were able to retain the memory normally for at least seven days. These results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory.

引用

页码：4166 / 4175

页数：10

共 29 条

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