Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors

被引：4

作者：

Casanova, M ^{[1
]}

Massimino, M ^{[1
]}

Ferrari, A ^{[1
]}

Spreafico, F ^{[1
]}

Piva, L ^{[1
]}

Coppa, J ^{[1
]}

Luksch, R ^{[1
]}

Cefalo, G ^{[1
]}

Terenziani, M ^{[1
]}

Polastri, D ^{[1
]}

Bellani, FF ^{[1
]}

Mazzaferro, V ^{[1
]}

机构：

[1] Ist Nazl Tumori, Pediat Oncol Unit, I-20133 Milan, Italy

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2005年 / 22卷 / 03期

关键词：

chemotherapy; cis platin; epirubicin; etoposide; hepatoblastoma; hepatocellular carcinoma;

D O I：

10.1080/08880010590921441

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To discuss the potential benefit of a chemotherapy regimen including etoposide ( etoposide, cis-platin, epirubicin [EPE]), the authors report a single-institutional experience regarding 13 children with hepatoblastoma (HB) and 7 with hepatocellular carcinoma (HCC). Chemotherapy achieved partial response in 8/9 HB and in 4/5 HCC. Eight initially unresectable HB subsequently had liver resection. Event-free survival and overall survival at 5 years were 84 and 88% for HB (nonmetastatic cases: 91 and 100%), 29% for HCC. EPE chemotherapy seems to be effective in the treatment of childhood malignant liver tumors. Etoposide could be suggested as part of intensive multidrug regimens for HCC and high-risk HB.

引用

页码：189 / 198

页数：10

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