Pilot study of feasibility of the effect of treatment with tDCS in patients suffering from treatment-resistant depression treated with escitalopram

被引:107
作者
Bennabi, D. [1 ,3 ]
Nicolier, M. [1 ,2 ,3 ]
Monnin, J. [1 ,2 ,3 ]
Tio, G. [1 ,2 ]
Pazart, L. [2 ]
Vandel, P. [1 ,2 ,3 ]
Haffen, E. [1 ,2 ,3 ]
机构
[1] Besancon Univ Hosp, Dept Clin Psychiat, F-25030 Besancon, France
[2] Univ Hosp Besancon, INSERM, CIC IT 1431, F-25030 Besancon, France
[3] Univ Franche Comte, Neurosci EA 481, F-25030 Besancon, France
关键词
Transcranial direct current stimulation; Depression; Treatment resistance; DIRECT-CURRENT STIMULATION; STAR-ASTERISK-D; MAJOR DEPRESSION; DOUBLE-BLIND; OUTCOMES; CORTEX;
D O I
10.1016/j.clinph.2014.09.026
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Objective: This double-blind, sham-controlled trial investigated the effects of two daily tDCS sessions over a 5-day period in treatment-resistant depression. Method: Twenty-four treatment-resistant depressed patients received two daily sessions of active or sham anodal tDCS to the left prefrontal cortex (2 mA, 10 sessions over 1 week). Depression severity, psychomotor retardation and cognitive function were assessed. Results: Active tDCS was not significantly superior to sham tDCS on the HDRS at week 4, as well as on the MADRS and SRRS scales, and on neuropsychological tests. Response rates were not significantly higher with active tDCS. tDCS was well tolerated, with mild adverse events limited to transient scalp discomfort. Conclusion: tDCS did not induce clinically relevant antidepressant effect in active and sham stimulation groups. There was no impact on psychomotor and neuropsychological functioning. Significance: tDCS efficacy on specific symptom profiles in pharmacotherapy-resistant depression is limited. The use of optimized stimulation protocol and longer period of follow up may valuably contribute to specify the place of tDCS in treatment-resistant depression. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1185 / 1189
页数:5
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