Deficit of interleukin 7 in septic patients

被引：24

作者：

Andreu-Ballester, Juan C. ^{[1
]}

Cuellar, Carmen ^{[2
]}

Garcia-Ballesteros, Carlos ^{[3
]}

Perez-Griera, Jaime ^{[4
]}

Amigo, Victoria ^{[3
]}

Peiro-Gomez, Ana ^{[5
]}

Penarroja-Otero, Carlos ^{[6
]}

Ballester, Ferran ^{[7
]}

Mayans, Jose ^{[3
]}

Tormo-Calandin, Constantino ^{[8
]}

机构：

[1] Arnau Vilanova Hosp, Res Dept, Valencia 46015, Spain

[2] Univ Complutense, Fac Pharm, Dept Parasitol, E-28040 Madrid, Spain

[3] Arnau Vilanova Hosp, Dept Hematol, Valencia 46015, Spain

[4] Clin Univ Hosp, Biopathol Dept, Valencia, Spain

[5] Arnau Vilanova Hosp, Emergency Dept, Valencia 46015, Spain

[6] Casa Salud Hosp, Valencia, Spain

[7] Univ Valencia, Fac Nursing, E-46003 Valencia, Spain

[8] Catholic Univ, Sch Med, Valencia, Spain

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 23卷 / 01期

关键词：

Interleukin; 7; Sepsis; Gamma-delta T cells; DISEASE SEVERITY; SEVERE SEPSIS; MANAGEMENT;

D O I：

10.1016/j.intimp.2014.08.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We recently demonstrated an overall decrease of all alpha beta and specially gamma delta T cell subsets in patients with sepsis compared with healthy subjects. IL-7 is a crucial factor for development of gamma delta T cells and survival in sepsis but its association with sepsis severity, evolution of organ failure and death still has not been investigated. Sera from 78 patients who met criteria for sepsis were analyzed vs control group. Septic patients showed the lowest levels of IL-7. Patients with severe sepsis reached levels of IL-7 higher than those observed in the groups of uncomplicated sepsis and septic shock. The frequency gamma delta T cells at admission was lower in septic patients vs control group. At the time of admission, the frequency of gamma delta T cells in septic patients who subsequently died was lower than the observed in the group of patients that instead survived. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：73 / 76

页数：4

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