Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels

被引:44
作者
Cho, JW
Baek, WK
Suh, SI
Yang, SH
Chang, J
Sung, YC
Suh, MH
机构
[1] Keimyung Univ, Sch Med, Dept Microbiol, Jung Gu, Taegu 700712, South Korea
[2] Seonam Univ, Coll Med, Dept Microbiol, Chunpook, South Korea
[3] Pohang Univ Sci & Technol, Dept Life Sci, Pohang, South Korea
来源
LIVER | 2001年 / 21卷 / 02期
关键词
hepatitis C virus; core protein; cyclin E; hepatocarcinogenesis;
D O I
10.1034/j.1600-0676.2001.021002137.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Aims/Background: The hepatitis C virus (HCV) core protein is known to Flay an important role in hepatocarcinogenesis. Recent studies have suggested that the increased proliferation rate of hepatocytes is a major risk factor for the development of hepatocellular carcinoma. In this study, we investigated whether the HCV core protein promotes the cell growth rate through the modulation of cyclin E expression levels. Methods/Results: HCV core stable transfectant Rat-1 cell lines showed a markedly increased proliferation rate compared to mock cells. Cyclin E expression and its associated kinase activities were remarkably increased in HCV core stable transfect;mts, Cyclin E mRNA levels were also upregulated in these eel lines. Conclusions: Our data suggest that the HCV core protein promotes cell proliferation through upregulation of the cyclin E expression levels, implying this property of HCV core protein plays an important role in hepatocarcinogenesis.
引用
收藏
页码:137 / 142
页数:6
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