Nandrolone decanoate treatment affects sarcoplasmic reticulum Ca2+ ATPase function in skinned rat slow- and fast-twitch fibres

被引：9

作者：

Bouhlel, A ^{[1
]}

Joumaa, WH ^{[1
]}

Léoty, C ^{[1
]}

机构：

[1] Univ Nantes, Fac Sci & Tech, CNRS, UMR 6018,Lab Physiol Gen, F-44322 Nantes 3, France

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2003年 / 446卷 / 06期

关键词：

SR calcium uptake; SR passive leak; anabolic-androgenic steroids; skinned fibres;

D O I：

10.1007/s00424-003-1114-z

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

The effects of anabolic-androgenic steroid administration on the function of the sarcoplasmic reticulum (SR) pump were investigated in chemically skinned fibres from the extensor digitorum longus (EDL) and soleus muscles of sedentary rats. Twenty male rats were divided into two groups, one group received an intramuscular injection of nandrolone decanoate (15 mg kg(-1)) weekly for 8 weeks, the second received similar weekly doses of vehicle (sterile peanut oil). Compared with control muscles, nandrolone decanoate treatment reduced SR Ca2+ loading in EDL and soleus fibres by 49% and 29%, respectively. In control and treated muscles, the rate of Ca2+ leakage depended on the quantity of Ca2+ loaded. Furthermore, for similar SR Ca2+ contents, the Ca2+ leakage rate was not significantly modified by nandrolone decanoate treatment. Nandrolone decanoate treatment thus affects Ca (2+) uptake by the SR in a fibre-type dependent manner.

引用

页码：728 / 734

页数：7

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