Experimental Atherosclerosis in Rabbits

被引：32

作者：

Dornas, Waleska C. ^{[1
]}

de Oliveira, Tania T.

Franklin Augusto, Luis E.

Nagem, Tanus J. ^{[1
]}

机构：

[1] Univ Fed Ouro Preto, Ouro Preto, MG, Brazil

来源：

ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2010年 / 95卷 / 02期

关键词：

NITRIC-OXIDE SYNTHASE; MESSENGER-RNA; CHOLESTEROL; 7-ALPHA-HYDROXYLASE; ENDOTHELIAL DYSFUNCTION; EXPERIMENTAL THROMBOSIS; DIETARY-CHOLESTEROL; VASCULAR FUNCTION; ANIMAL-MODEL; IN-VIVO; HYPERCHOLESTEROLEMIA;

D O I：

10.1590/S0066-782X2010001200020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Many researches have been conducted in experimental models in order to study the development of atherosclerosis from hyperlipidemia-inducing diets. Since rabbits are very sensitive to cholesterol-rich diets and accumulate large amounts of cholesterol in their plasma, their use as experimental models to evaluate the development of atherosclerosis is highly relevant and brings information on factors that contribute to the progression and regression of this condition that can be applied to humans. As such, this review includes studies on the atherogenic function of cholesterol based on rabbits as the experimental model, since they have become the most largely used experimental model of atherosclerosis.

引用

页码：272 / 278

页数：7

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