Magnetically amplified DNA assays (MADA): Sensing of viral DNA and single-base mismatches by using nucleic acid modified magnetic particles

被引：113

作者：

Patolsky, F ^{[1
]}

Weizmann, Y ^{[1
]}

Katz, E ^{[1
]}

Willner, I ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Farkas Ctr Light Induced Proc, Inst Chem, IL-91904 Jerusalem, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 21期

关键词：

biosensors; chemiluminescence; DNA; magnetic particles;

D O I：

10.1002/anie.200250379

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Taking DNA analysis for a spin: Amplified detection of viral DNA and single-base mutations in nucleic acids is accomplished by the thermally cycled incorporation of biotin labels into DNA replica associated with magnetic particles, by the electrocatalyzed biochemiluminescence transduction of the DNA recognition events, and by the rotation of the magnetic particles on electrode surfaces (see schematic representation).

引用

页码：2372 / 2376

页数：5

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