Opinion - Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis

被引：350

作者：

Stingl, John

Caldas, Carlos ^{[1
]}

机构：

[1] Univ Cambridge, Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge CB2 0RE, England

[2] Univ Cambridge, Li Ka Shing Ctr, Dept Oncol, Cambridge CB2 0RE, England

[3] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 10期

关键词：

D O I：

10.1038/nrc2212

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human breast cancers are heterogeneous, both in their pathology and in their molecular profiles. This suggests the hypothesis that breast cancers can initiate in different cell types, either breast epithelial stem cells or their progeny ( transit amplifying cells or committed differentiated cells). In this respect, breast cancer could be viewed as being similar to haematological malignancies for which an analogous model has been proposed. Drawing such parallels might help to unravel the molecular nature of the initiating events in breast cancer and might have substantial clinical implications.

引用

页码：791 / 799

页数：9

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