Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series

被引：74

作者：

Magiatis, P

Melliou, E

Skaltsounis, AL

Mitaku, S ^{[1
]}

Léonce, S

Renard, P

Pierré, A

Atassi, G

机构：

[1] Univ Athens, Lab Pharmacognosy, GR-15771 Athens, Greece

[2] Inst Rech Servier, F-92150 Suresnes, France

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 08期

关键词：

D O I：

10.1021/np9800295

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The synthesis of known (3-6) and new (7-10 and 14-22) coumarins in the seselin and xanthyletin series is described. The cytotoxic activity of compounds 3-22 was carried out in vitro on L-1210 cells. The most active compounds were 9, 16, 18, and 20 in the seselin series and 10, 17, and 19 in the xanthyletin series. Structure-activity relationships are discussed.

引用

页码：982 / 986

页数：5

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[3]

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