Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans

被引：170

作者：

Rubin-Bejerano, I

Fraser, I

Grisafi, P

Fink, GR ^{[1
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02142 USA

[2] Massachusetts Gen Hosp, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 19期

关键词：

D O I：

10.1073/pnas.1834481100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The transcriptional profiles of yeast cells that have been phagocytosed by either human neutrophils or monocytes were compared by using whole genome arrays. After phagocytosis by neutrophils, both Saccharomyces cerevisiae and Candida albicans respond by inducing genes of the methionine and arginine pathways. Neither of these pathways is induced upon phagocytosis by monocytes. Both fungi show a similar induction of these pathways when transferred from amino acid-rich medium to amino acid-deficient medium. These data suggest that the internal phagosome of the neutrophil is an amino acid-deficient environment.

引用

页码：11007 / 11012

页数：6

共 21 条

[1] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT
BABIOR, BM
KIPNES, RS
CURNUTTE, JT
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) : 741 - 744
[2] BENNETT RJ, 2003, IN PRESS MOL CELL BI
[3] Remodeling of yeast genome expression in response to environmental changes
Causton, HC
Ren, B
Koh, SS
Harbison, CT
Kanin, E
Jennings, EG
Lee, TI
True, HL
Lander, ES
Young, RA
[J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (02) : 323 - 337
[4] Plasma amino acid levels with a note on membrane transport: Characteristics, regulation, and metabolic significance
Cynober, LA
[J]. NUTRITION, 2002, 18 (09) : 761 - 766
[5] Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
Eriksson, S
Lucchini, S
Thompson, A
Rhen, M
Hinton, JCD
[J]. MOLECULAR MICROBIOLOGY, 2003, 47 (01) : 103 - 118
[6] Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
Gagnon, E
Duclos, S
Rondeau, C
Chevet, E
Cameron, PH
Steele-Mortimer, O
Paiement, J
Bergeron, JJM
Desjardins, M
[J]. CELL, 2002, 110 (01) : 119 - 131
[7] Genomic expression programs in the response of yeast cells to environmental changes
Gasch, AP
Spellman, PT
Kao, CM
Carmel-Harel, O
Eisen, MB
Storz, G
Botstein, D
Brown, PO
[J]. MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (12) : 4241 - 4257
[8] Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress
Hinnebusch, AG
Natarajan, K
[J]. EUKARYOTIC CELL, 2002, 1 (01) : 22 - 32
[9] Isocitrate lyase is essential for pathogenicity of the fungus leptosphaeria maculans to canola (Brassica napus)
Idnurm, A
Howlett, BJ
[J]. EUKARYOTIC CELL, 2002, 1 (05) : 719 - 724
[10] Nonfilamentous C-albicans mutants are avirulent
Lo, HJ
Kohler, JR
DiDomenico, B
Loebenberg, D
Cacciapuoti, A
Fink, GR
[J]. CELL, 1997, 90 (05) : 939 - 949

← 1 2 3 →