Azonia derivatives of the gamma-carboline system. A new class of DNA intercalators

被引：17

作者：

Molina, A

Vaquero, JJ

GarciaNavio, JL

AlvarezBuilla, J

Rodrigo, MM

Castano, O

deAndres, JL

机构：

[1] UNIV ALCALA DE HENARES, DEPT QUIM ORGAN, E-28871 ALCALA DE HENARES, SPAIN

[2] UNIV ALCALA DE HENARES, DEPT QUIM FIS, E-28871 ALCALA DE HENARES, SPAIN

[3] UNIV GIRONA, INST QUIM COMPUTAC, GIRONA 17071, SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(96)00243-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Methyl-gamma-carboline derivatives were transformed into the corresponding N-aminoazinium salts, which were condensed with 1,2-dicarbonyl compounds (Westphal reaction) to afford azonia derivatives with a bridgehead quaternary nitrogen atom. Some of them show DNA intercalating properties. Copyright (C) 1996 Elsevier Science Ltd

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页码：1453 / 1456

页数：4

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