Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases

被引：160

作者：

Ben-Ami, Eyal ^{[1
]}

Berrih-Aknin, Sonia ^{[2
]}

Miller, Ariel ^{[1
,3
,4
]}

机构：

[1] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel

[2] UPMC, Inst Myol, UMRS 974, Paris, France

[3] Carmel Hosp, Neuroimmunol Unit, Haifa, Israel

[4] Carmel Hosp, Multiple Sclerosis Ctr, Haifa, Israel

来源：

AUTOIMMUNITY REVIEWS | 2011年 / 10卷 / 07期

关键词：

Mesenchymal stem cells; Cellular therapy; Immunomodulation; Autoimmune diseases; Multiple sclerosis; Myasthenia gravis; SUPPRESS T-LYMPHOCYTE; STROMAL CELLS; IN-VITRO; MYASTHENIA-GRAVIS; INTERFERON-GAMMA; PROGENITOR CELLS; HEALTHY DONORS; NITRIC-OXIDE; PROLIFERATION; INHIBIT;

D O I：

10.1016/j.autrev.2011.01.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent progenitor cells which can be isolated from various human adult tissues. In recent years. MSCs have been shown to possess broad immunoregulatory capabilities, modulating both adaptive and innate immunity. This review discusses the documented immunomodulatory capabilities of the MSCs, the possible mechanisms underlying these functions and presents the potential of using this stem cell-based approach as an immunomodulatory tool for the treatment of autoimmune diseases. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：410 / 415

页数：6

共 76 条

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