Investigation of PVA/ws-chitosan hydrogels prepared by combined γ-irradiation and freeze-thawing

被引：205

作者：

Yang, Xiaomin ^{[1
,2
]}

Liu, Q. ^{[1
,2
]}

Chen, Xiliang ^{[1
,2
]}

Yu, Feng ^{[1
,2
]}

Zhu, Zhiyong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2008年 / 73卷 / 03期

关键词：

hydrogels; freeze-thawing; irradiation; rheology; water soluble chitosan;

D O I：

10.1016/j.carbpol.2007.12.008

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

gamma-Irradiation combined with freeze-thawing, i.e. irradiation followed by freeze-thawing and freezc-thawing followed by irradiation, was applied to prepare poly(vinyl alcohol) (PVA)/water soluble chitosan (ws-chitosan) hydrogels for wound dressing. The properties of these hydrogels were investigated and compared to those prepared by freeze-thawing and by irradiation, respectively. Hydrogels made by irradiation followed by freeze-thawing show larger swelling capacity and mechanical strength, higher thermal stability, lower water evaporation rate, and are less turbid than those made by pure freeze-thawing and freeze-thawing followed by irradiation. Hydrogels made by irradiation alone cannot be used as wound dressing due to their poor mechanical strength. SEM results show that the final structure of hydrogels made by combined irradiation and freeze-thawing is mainly determined by the first processing step. It is found that the appropriate amount of ws-chitosan can endow hydrogels with large swelling capacity and mechanical strength. The presence of ws-chitosan provides the hydrogels with good antibacterial activity against Escherichia coli (E. coli). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：401 / 408

页数：8

共 31 条

[1]

Preparation and characterization of biocompatible spongy cryogels of poly(vinyl alcohol)-gelatin and study of water sorption behaviour [J].