Transcriptional analysis of targets in multiple sclerosis

被引：94

作者：

Steinman, L ^{[1
]}

Zamvil, S ^{[1
]}

机构：

[1] Stanford Univ, Beckman Ctr Mol Med B002, Stanford, CA 94305 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1038/nri1108

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Large-scale analyses of messenger RNA transcripts and autoantibody responses, taken from the actual sites of disease, provide us with an unprecedented view of the complexity of autoimmunity. Despite an appreciation of the large number of pathways and pathological processes that are involved in these diseases, a few practical targets and several new strategies have emerged from these studies. This review focuses on multiple sclerosis and on the approaches that are being used to identify new targets that might be manipulated to control this disease.

引用

页码：483 / 492

页数：10

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