Bidirectional signaling between Yersinia and its target cell

被引：7

作者：

Fallman, M ^{[1
]}

Persson, C ^{[1
]}

Schesser, K ^{[1
]}

Wolf-Watz, H ^{[1
]}

机构：

[1] Umea Univ, Dept Cell & Mol Biol, S-90187 Umea, Sweden

来源：

FOLIA MICROBIOLOGICA | 1998年 / 43卷 / 03期

关键词：

D O I：

10.1007/BF02818611

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Preventing the early host immune defense allows pathogenic Yersinia to proliferate in lymphatic tissue. This ability depends on signaling that occurs between the bacteria and the host cells. Following intimate contact with the target cell a signal is generated within the bacterium that results in increased expression of virulence-associated proteins that are subsequently delivered into the infected cell. These proteins, designated Yops, interfere with the host-cell signaling pathways that are normally activated to eliminate infectious agents.

引用

收藏

页码：263 / 273

页数：11

相关论文

共 82 条

[1] MUTATIONAL ANALYSIS OF THE YERSINIA-ENTEROCOLITICA VIRC OPERON - CHARACTERIZATION OF YSCE, YSCF, YSCG, YSCI, YSCJ, YSCK REQUIRED FOR YOP SECRETION AND YSCH ENCODING YOPR [J].

ALLAOUI, A ;

SCHULTE, R ;

CORNELIS, GR .

MOLECULAR MICROBIOLOGY, 1995, 18 (02) :343-355

[2] YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis [J].

Andersson, K ;

Carballeira, N ;

Magnusson, KE ;

Persson, C ;

Stendahl, O ;

WolfWatz, H ;

Fallman, M .

MOLECULAR MICROBIOLOGY, 1996, 20 (05) :1057-1069

[3] THE INDUCIBLE TRANSCRIPTION ACTIVATOR NF-KAPPA-B - REGULATION BY DISTINCT PROTEIN SUBUNITS [J].

BAEUERLE, PA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (01) :63-80

[4] I-KAPPA-B INTERACTS WITH THE NUCLEAR-LOCALIZATION SEQUENCES OF THE SUBUNITS OF NF-KAPPA-B - A MECHANISM FOR CYTOPLASMIC RETENTION [J].

BEG, AA ;

RUBEN, SM ;

SCHEINMAN, RI ;

HASKILL, S ;

ROSEN, CA ;

BALDWIN, AS .

GENES & DEVELOPMENT, 1992, 6 (10) :1899-1913

[5] THE LCRB (YSCN/U) GENE-CLUSTER OF YERSINIA-PSEUDOTUBERCULOSIS IS INVOLVED IN YOP SECRETION AND SHOWS HIGH HOMOLOGY TO THE SPA GENE CLUSTERS OF SHIGELLA-FLEXNERI AND SALMONELLA-TYPHIMURIUM [J].

BERGMAN, T ;

ERICKSON, K ;

GALYOV, E ;

PERSSON, C ;

WOLFWATZ, H .

JOURNAL OF BACTERIOLOGY, 1994, 176 (09) :2619-2626

[6] THE YERSINIA TYROSINE PHOSPHATASE - SPECIFICITY OF A BACTERIAL VIRULENCE DETERMINANT FOR PHOSPHOPROTEINS IN THE J774A.1 MACROPHAGE [J].

BLISKA, JB ;

CLEMENS, JC ;

DIXON, JE ;

FALKOW, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (06) :1625-1630

[7] Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y-enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus [J].

Boland, A ;

Sory, MP ;

Iriarte, M ;

Kerbourch, C ;

Wattiau, P ;

Cornelis, GR .

EMBO JOURNAL, 1996, 15 (19) :5191-5201

[8] THE PLASMID-ENCODED YOP2B PROTEIN OF YERSINIA-PSEUDOTUBERCULOSIS IS A VIRULENCE DETERMINANT REGULATED BY CALCIUM AND TEMPERATURE AT THE LEVEL OF TRANSCRIPTION [J].

BOLIN, I ;

WOLFWATZ, H .

MOLECULAR MICROBIOLOGY, 1988, 2 (02) :237-245

[9] A model of host-microbial interactions in an open mammalian ecosystem [J].

Bry, L ;

Falk, PG ;

Midtvedt, T ;

Gordon, JI .

SCIENCE, 1996, 273 (5280) :1380-1383

[10]

Burnham MR, 1996, ONCOGENE, V12, P2467

← 1 2 3 4 5 6 7 8 9 →