An improved method for the palladium cross-coupling reaction of oxazol-2-ylzinc derivatives with aryl bromides

被引：34

作者：

Reeder, MR ^{[1
]}

Gleaves, HE ^{[1
]}

Hoover, SA ^{[1
]}

Imbordino, RJ ^{[1
]}

Pangborn, JJ ^{[1
]}

机构：

[1] Pfizer Inc, Early Proc Res & Dev, Kalamazoo, MI 49001 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 05期

关键词：

D O I：

10.1021/op034059c

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An improved and scalable procedure to couple ozaxole and thiazole to aryl halides has been demonstrated. The required organozinc reagents were prepared from the aryllithium and solid ZnCl2. These reagents have been successfully coupled to a variety of aryl bromides and aryl iodides in good to excellent yields.

引用

页码：696 / 699

页数：4

共 6 条

[1]

Anderson BA, 1996, SYNTHESIS-STUTTGART, P583

[2]

DONDONI A, 1987, SYNTHESIS-STUTTGART, P693

[3]

FANTUCCI M, 1997, Patent No. 9831687

[4] The equilibrium between 2-lithium-oxazole(-thiazole, -imidazole) derivatives and their acyclic isomers - A structural investigation [J].

Hilf, C ;

Bosold, F ;

Harms, K ;

Marsch, M ;

Boche, G .

CHEMISCHE BERICHTE-RECUEIL, 1997, 130 (09) :1213-1221

[5] REACTIONS OF LITHIOOXAZOLE [J].

HODGES, JC ;

PATT, WC ;

CONNOLLY, CJ .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (01) :449-452

[6] Metalation of oxazole-borane complexes: A practical solution to the problem of electrocyclic ring opening of 2-lithiooxazoles [J].

Vedejs, E ;

Monahan, SD .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (16) :5192-5193

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