A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice

被引：54

作者：

Wakimoto, K

Chiba, H

Michibata, H

Seishima, M

Kawasaki, S

Okubo, K

Mitsui, H

Torii, H

Imai, Y

机构：

[1] Tanabe Seiyaku Co Ltd, Adv Med Res Dept, Discovery Res Lab, Yodogawa Ku, Osaka 5328505, Japan

[2] Ogaki Municipal Hosp, Dept Dermatol, Ogaki 5038502, Japan

[3] Kyoto Prefectural Univ Med, Dept Ophthalmol, Kamigyo Ku, Kyoto 6028566, Japan

[4] Kyushu Univ, Med Inst Bioregulat, Higashi Ku, Fukuoka 8128582, Japan

[5] Univ Tokyo, Grad Sch Med, Dept Dermatol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 310卷 / 02期

关键词：

DGAT; psoriasis; diabetes; triglyceride;

D O I：

10.1016/j.bbrc.2003.09.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis is a skin disease with epidermal keratinocyte hyperproliferation and altered differentiation. To identify novel psoriasis-related genes, we investigated differentially expressed genes between normal and psoriatic skin. We identified a novel acyl CoA:diacylglycerol acyltransferase 2 (DGAT2) gene, which was decreased in human psoriatic skin. DGAT2 mRNA was expressed in sebaceous glands of normal human skin. DGAT2 protein was detected on endoplasmic reticulum. DGAT2 catalyzes the final step in the production of triglycerides and the accumulation of triglycerides in the tissues is considered to be related to insulin resistance. Therefore, we also investigated the expression of the DGAT2 gene in diabetic mice. DGAT2 mRNA was increased in the adipose, small intestine, and skeletal muscle in diabetic mice. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：296 / 302

页数：7

共 29 条

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