Cartilage proteoglycans

被引：456

作者：

Knudson, CB ^{[1
]}

Knudson, W ^{[1
]}

机构：

[1] Rush Med Coll, Rush Presbyterian St Lukes Med Ctr, Dept Biochem, Chicago, IL 60612 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 02期

关键词：

aggrecan; cartilage; CD44; chondrocytes; hyaluronan;

D O I：

10.1006/scdb.2000.0243

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The predominant proteoglycan Present in cartilage is the large chondroitin sulfate proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a supramolecular structure with as many as 50 monomers bound to a filament of hyaluronan. Aggrecan serves a direct, parameter role providing the osmotic resistance necessary for cartilage to resist compressive loads. Other proteoglycans expressed during chondrogenesis and in cartilage include the cell surface syndecans and glypican, the small leucine-rich proteoglycans decorin, biglycan, fibromodulin, lumican and epiphycan and the basement membrane proteoglycan, perlecan. The emerging functions of these proteoglycans in cartilage will enhance our understanding of chondrogenesis and cartilage degeneration.

引用

页码：69 / 78

页数：10

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