A comparison of day 5 and day 6 blastocyst transfers

被引:120
作者
Shapiro, BS
Richter, KS
Harris, DC
Daneshmand, ST
机构
[1] Fertil Ctr Las Vegas, Las Vegas, NV 89117 USA
[2] Univ Nevada, Sch Med, Dept Obstet & Gynecol, Las Vegas, NV 89154 USA
关键词
blastocyst transfer; blastocyst expansion; in vitro fertilization; day 5 blastocyst transfer; day 6 blastocyst transfer; implantation rate; pregnancy rate;
D O I
10.1016/S0015-0282(01)01771-X
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To compare implantation and pregnancy rates according to the day of embryo transfer (day 5 or 6 after oocyte retrieval) when transfer was postponed until expanded blastocysts developed. Design: Retrospective clinical study. Setting: Private ART center. Patient(s): One-hundred and eighty-three women undergoing blastocyst-stage embryo transfer following in vitro fertilization. Intervention(s): Bipronucleate oocytes were grown for up to 144 hours and subsequently transferred only when at least one embryo attained the expanded blastocyst stage. Main Outcome Measure(s): Implantation and pregnancy rates. Result(s): Blastocysts transferred on day 5 implanted at nearly twice the rate of blastocysts transferred on day 6 (36.3% vs. 19.0%). Pregnancy rates were also almost twice as high among the day 5 transfer patients (59.3% vs. 32.3%). In addition, more blastocysts developed (3.6 vs. 2.4), and more were transferred (2.7 vs. 2.3) to the day 5 transfer patients, although the proportion of expanded blastocysts among the blastocysts that were transferred was the same for the two groups (91.7% vs. 93.6%). Conclusion(s): Embryos that develop to the expanded blastocyst stage and are transferred on day 5 after retrieval are approximately twice as likely to implant compared to those for which expansion and transfer are delayed until day 6. (Fertil Steril(R) 2001;75:1126-30. (C)2001 by American Society for Reproductive Medicine.).
引用
收藏
页码:1126 / 1130
页数:5
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